l基本信息：

姓名：关意佳

性别：女

出生年月：1988.12

最终学历（学位）：博士

联系方式：（电子邮件或电话）

邮箱：guanyj@hpu.edu.cn

l教育（工作）经历：

2018.01-今 河南理工大学 材料科学与工程学院 材料化学系 讲师

2012.09-2018.01 中国科学院大学 长春应用化学研究所 无机化学 博士

2008.09-2012.06 华中科技大学 化学与化工学院 应用化学专业 学士

l教学情况：

主讲《生物医学材料》、《功能高分子》本科生课程

l科研领域：

1、多功能无机药物试剂抑制Aβ聚集的机理研究

2、纳米材料促神经干细胞分化及神经突触生长的机理研究

l科研成果：

近年来在Science advances, biomaterials,small, Chemistry-aEuropeanjournal, Chemical Communications等国际知名杂志以第一作者或通讯作者身份发表论文6篇。主持国家级基金1项，校级基金1项；参与国家自然科学基金2项。

科研项目：

1、国家自然科学基金青年科学基金项目，智能纳米材料选择性清除β-淀粉样肽及缓解其神经毒性的机理研究，2020/01-2022/12，25万元，主持。

2、河南理工大学博士基金，光调控的程序性药物释放体系的构建及其在神经退行性疾病中的治疗研究，2018-2021，6万元，主持。

3、国家自然科学基金面上项目，靶向高级G-四链体DNA的配体的合成与筛选及其作用机制研究，2016/01-2019/12，65万，参与。

4、国家自然科学基金青年科学基金项目，基于氧化铈纳米粒子的多功能载药体系的构建，2015/01-2017/12，25万，参与。

代表论文：

[1] Yijia Guan, Dongqin Yu, Hanjun Sun,Jingsong Ren, Xiaogang Qu^*,Aβ aggregation behavior at interfaces with switchablewettability: a bioinspired perspective to understand amyloid formation,Chemical Communication,2021, doi: 10.1039/D0CC07546A

[2] Yijia Guan,Zhi Du, Nan Gao, Yue Cao, Xiaohui Wang, Peter Scott, Hualong Song, JinsongRen, Xiaogang Qu^*, Stereochemistry and amyloid inhibition:Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide.ScienceAdvances,2018,4(1): eaao6718.

[3] Yijia Guan,Nan Gao, Jinsong Ren, Xiaogang Qu^*,A rationally designed CeNP@MnMoS4 core-shell nanoparticles for modulatingmultiple facets of Alzheimer’s Disease. Chem-Eur J.2016,22,14523–14526.

[4] Yijia Guan,Meng Li, Kai Dong, Nan Gao, Jinsong Ren, Xiaogang Qu^*,Ceria/POMs hybrid nanoparticles as a mimicking metallopeptidase for treatmentof neurotoxicity of amyloid-β peptide.Biomaterials,2016,98,92–102.

[5] Yijia Guan,Meng Li, Kai Dong, Jinsong Ren, Xiaogang Qu^*, NIR-Responsiveupconversion nanoparticles stimulate neurite outgrowth in PC12 cells.Small,2014,10, 3655–3661.

[6] Dongqin Yu^#,Yijia Guan^#, Fuquan Bai, Zhi Du, Nan Gao,Jinsong Ren, Xiaogang Qu^*, Metal-Organic Frameworks Harness CuChelating and Potooxidation Against Amyloid β Aggregation in vivo, Chemistry-AEuropean Journal,2019, 25, 3489-3495.

[7] 关意佳,曲晓刚^*,利用稀土功能材料调控细胞行为的新进展,中国稀土学报,2017,35(1): 152 –162.

[8] Zhi Du,YijiaGuan, Chao Ding, Nan Gao, Jinsong Ren, Xiaogang Qu^*,Cross-fibrillation of insulin and amyloid β on chiral surfaces: Chiralityaffects aggregation kinetics and cytotoxicity, Nano Research,2018,11(8), 4102-4110.

[9] Meng Li,Yijia Guan, Andong Zhao, Jinsong Ren, XiaogangQu^*, Using multifunctional peptide conjugated Aunanorods for monitoring β-amyloid aggregation and chemo-photothermal treatmentof Alzheimer’s Disease.Theranostics,2017,7,2996–3006.

[10] Meng Li,Yijia Guan, ZhaoweiChen, Nan Gao, Jinsong Ren, Kai Dong, Xiaogang Qu^*, Platinum-coordinated graphitic carbon nitridenanosheet used for targeted inhibition of amyloid β-peptide aggregation.NanoResearch,2016,9, 2411–2423.

[11] Meng Li,Yijia Guan, Chao Ding,Zhaowei Chen, Jinsong Ren, Xiaogang Qu^*, An ultrathin graphitic carbon nitridenanosheet: a novel inhibitor of metal-induced amyloid aggregation associatedwith Alzheimer’s disease.J. Mater. Chem. B,2016,4,4072–4075.

[12] Haiwei Ji,Yijia Guan, Li Wu,Jinsong Ren, Miyoshi D., Sugimoto N., Xiaogang Qu^*, A fluorescent probe for detection of anintracellular prognostic indicator in early-stage cancer.Chem. Commun.2015,51, 1479–1482.

[13] Zhijun Zhang,Yijia Guan, MengLi, Andong Zhao, Jinsong Ren, Xiaogang Qu^*, Highly stable and reusable imprinted artificialantibody used for in situ detection and disinfection of pathogens.Chem.Sci.2015,6, 2822–2826.

其他：

课题组常年招收具有化学、分子生物学、材料学、高分子等背景相关专业的硕士。有意向者请发送简历至邮箱：guanyj@hpu.edu.cn